Tumor Flare Syndrome | Metastatic Carcinoma to Bone

Did the patient show a worsening of symptoms within a few days or weeks of starting therapy with a hormonal or anti-hormonal agent?

Time in weeks since the therapy was started

Has the patient developed hypercalcemia during this interval?

Did metastatic lesions initially progress on imaging studies after starting the therapy?

Did serum tumor marker(s) increase after starting the therapy?

Have the symptoms decreased in severity?

Have the metastatic lesions regressed in followup imaging studies?

Severity of pain